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Publications

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2024

  • Bajikar SS, Sztainberg Y, Trostle AJ, Tirumala HP, Wan YW, Harrop CL, Bengtsson JD, Carvalho CMB, Pehlivan D, Suter B, Neul JL, Liu Z, Jafar-Nejad P, Rigo F, Zoghbi HY. (2024) Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels. Hum Mol Genet, Sept 2024:ddae135. https://doi.org/10.1093/hmg/ddae135

2023

  • Zhou J*, Cattoglio C*, Shao Y*, Tirumala HP, Vetralla C, Bajikar SS, Li Y, Chen H, Wang Q, Wu Z, Tang B, Zahabiyon M, Bajic A, Meng X, Ferrie JJ, LaGrone, Zhang P, Kim JJ, Tang J, Liu Z, Darzacq X, Heintz H, Tijan R, Zoghbi HY. (2023) A novel pathogenic mutation of MeCP2 imparts chromatin association independent of protein levels. Genes Dev, 37, 883-900. doi:10.1101/gad.350733.123

  • Bajikar SS, Anderson AG, Zhou J, Durham MA, Trostle AJ, Wan YW, Liu Z, Zoghbi HY. (2023) MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function. eLife, 12:e83806. https://doi.org/10.7554/eLife.83806 
     

2022

  • Zhou J, Hamdan H, Yalamanchili HK, Pang K, Pohodich AE, Lopez J, Shao Y, Oses-Prieto JA, Li L, Kim W, Durham MA, Bajikar SS, Palmer DJ, Ng P, Thompson ML, Bebin EM, Muller AJ, Kuechler A, Kampmeier A, Haack TB, Burlingame. AL, Liu Z, Rasband MN, Zoghbi HY. (2022) Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders. Proc Natl Acad Sci, 119(4). https://doi.org/10.1073/pnas.2119078119
     

2021

  • Ravenscroft TA, Phillips JB, Fieg E, Bajikar SS, Peirce J, Wegner J, Luna AA, Fox EJ, Yan Y-L, Rosenfeld JA, Zirin J, Kanca O, Benke PJ, Cameron ES, Strehlow V, Platzer K, Jamra RA, Klockner C, Osmond M, Licata T, Rojas S, Dyment. D, Chong JSC, Lincoln S, Sotler HM, Postelhwait JH, Wangler MF, Yamamoto S, Krier J, Westerfield M, Bellen HJ. (2021) Heterozygous loss-of-function variants significantly expand the phenotypes associated with loss of GDF11. Genet Med, 1-12. https://doi.org/10.1038/s41436-021-01216-8

  • Shao Y, Bajikar SS, Tirumala HP, Gutierrez MC, Wythe JD, Zoghbi HY. (2021) Identification and characterization of conserved non-coding cis-regulatory elements that impact Mecp2 expression and neurological functions. Genes Dev, 35, 489-494. http://www.genesdev.org/cgi/doi/10.1101/gad.345397.120

  • Shao Y, Sztainberg Y, Wang Q, Bajikar SS, Trostle AJ, Wan YW, Jafar-Nejad P, Rigo F, Liu Z, Tang J, Zoghbi HY. (2021) Antisense oligonucleotide therapy in a humanized mouse model of MECP2 duplication syndrome. Sci Trans Med, 13, 583. doi: 10.1126/scitranslmed.aaz7785  
     

Before 2020

  • Borten MA*, Bajikar SS*, Sasaki N, Clevers H, Janes KA.  (2018) Automated brightfield morphometry of 3D organoid populations by OrganoSeg. Sci Rep, 1, 5319.  *Equal contribution. https://doi.org/10.1038/s41598-017-18815-8

    • Highlighted as top 2% downloaded cell and molecular biology article
       

  • Bajikar SS, Wang CC, Borten MA, Atkins KA, Janes KA.  (2017) GDF11 tumor suppression is sequestered by triple-negative breast cancer cells. Dev Cell, 43, 418-435. https://doi.org/10.1016/j.devcel.2017.10.027
     

  • Bajikar SS*, Fuchs C*, Roller A, Theis FJ, Janes KA. (2014) Parameterizing cell-to-cell regulatory heterogeneities via stochastic transcriptional profiles. Proc Natl Acad Sci, 111, E626-35. *Equal contribution. https://doi.org/10.1073/pnas.131164711

  • Wang CC, Bajikar SS, Jamal L, Atkins KA, Janes KA. (2014) A time- and matrix- dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies. Nat Cell Biol, 16, 345-56. https://doi.org/10.1038/ncb2930

  • Bajikar SS, Janes KA. (2012) Multiscale models of cell signaling. Ann Biomed Eng, 40, 2319-2327.

    https://doi.org/10.1007/s10439-012-0560-1
     

  • Nickerson MM, Song J, Meisner JK, Bajikar SS, Burke CW, Shuptrine CW, Owens GK, Skalak TC, Price RJ. (2009) Bone Marrow-Derived Cell-Specific Chemokine (C-C Motif) Receptor-2 Expression is Required for Arteriolar Remodeling. Arterioscler Thromb Vasc Biol, 29, 1794-1801. https://doi.org/10.1161/ATVBAHA.109.194019

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